Police said the stabbed man was found on Hospital Road and died a short time later.
Ch Supt Kevin Mulligan, who heads Greater Manchester Police's Salford division, said the man suffered "at least one stab wound" during an altercation in the house involving at least one person from the address and four people breaking in.
He said he could not comment further on the injuries or the cause of death until a post-mortem examination had been carried out.
Jesus, so four people break into someone's house and the householder gets stabbed to death?
Well, no, not exactly.
A burglar has been stabbed to death and the householder arrested on suspicion of murder after an attempted break-in at his house in Salford.
Four masked men attempted to get into a house in Ethel Avenue before midnight on Wednesday.
So, four masked men broke into someone's house and one of the intruders got stabbed and died. Well, them's the breaks, the stabber was probably scared out of his wits. The fact that there was only one stabee and that he only got stuck once would suggest that this was not a frenzied, rage fuelled attack of revenge. Preditcably:
Peter Flanagan, 57, son Neil, 29, and his son's girlfriend are being held.
The men and the 21-year-old woman are being questioned on suspicion of murder.
I cannot and do not support the death penalty, but if you and three mates mask up and break into someone's house, all bets are off. This, from the evidence at hand, seems to be a clear case of defense of property and life. In my opinion, a murder charge is not appropriate.
It is possible that the CPS will go for manslaughter, but even though the defender may end up escaping a jail term, he or she will still be stuck with a criminal record that could effect their life for the rest of their days. It seems unfair in the extreme to me.
Meanwhile over the pond:
No problem for law enforcement over there, and quite right too, you cannot cross someone's threshold and expect to be protected. IF the homeowner is lying in wait with the plan to kill the intruder, that is different, but in my opinion in a heat of the moment reaction there should be only one outcome. No charge.
Just to show there's no honour amongst thieves:
The stabbed man, 26, is believed to have been carried away by the other intruders as they fled, before being dumped in a street in Pendlebury.